It is suggested in the original series that Barney grew up at 142 Boulder Avenue in Granitetown. The original series also suggested in one episode that Barney was the nephew of Fred's boss, Mr. Slate.
Barney is a happy jovial neighbor to the Flintstones.
Barney was also a member of the Loyal Order of Water Buffalos lodge and its predecessor in earlier episodes, the Loyal Order of Dinosaurs. He is also a talented pianist and drummer. In the first episode of the original series he was an inventor of a human-powered helicopter. Though clearly depicted as being in better shape than Fred, he isn't shown to be quite as enthusiastic a sportsman as Fred is. This distinction can be attributed to Fred's fondness of food, though Barney is shown to be almost as capable of excessive appetite on a number of occasions.
Betty tends to socialize with Wilma. She takes care of her husband but is always rescuing him from Fred's backfiring schemes.
Adopted only son. He turns out to the strongest baby in the world.
Barney participates in Fred's schemes because he is his friend. Usually after Fred had hatched one of his plans, Barney would usually show reservations but then agree by laughing and saying "er huh huh... OK, Fred!" or "huh huh huh... whatever you say, Fred!"
Wilma is Betty's friend but she seems nicer to Barney than she is to her own husband.
- Barney's personality was based on that of Ed Norton on the 1950s television series The Honeymooners, played by Art Carney.
- Mel Blanc, who voiced Barney, first used the Barney Rubble voice when imitating Norton in the 1956 Looney Tunes cartoon Half-Fare Hare.